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ORIGINAL ARTICLE
Year : 2019  |  Volume : 11  |  Issue : 1  |  Page : 20-24

Evaluation of salivary levels of visfatin in obese patients with chronic periodontitis


1 Department of Periodontology, Hazaribag College of Dental Sciences and Hospital, Demotand, Hazaribag, Jharkhand, India
2 Department of Periodontology, Uttaranchal Dental and Medical Research Institute, Dehradun, Uttarakhand, India
3 Department of Orthodontics and Dentofacial Orthopedics, Uttaranchal Dental and Medical Research Institute, Dehradun, Uttarakhand, India
4 Department of Orthodontics, Teerthanker Mahaveer Dental College and Research Centre, Moradabad, Uttar Pradesh, India
5 Department of Dentofacial Orthopedics and Prosthodontics and Crown and Bridge, Teerthanker Mahaveer Dental College and Research Centre, Moradabad, Uttar Pradesh, India
6 Department of Periodontology, Universal College of Medical Sciences, Bhairahwa, Nepal

Correspondence Address:
Vivek Kumar
House No. 308/A, Prasad Flour Mill Road, Doranda, Ranchi, Jharkhand
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/IJDS.IJDS_92_18

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Background: Visfatin, also known as nicotinamide phosphoribosyltransferase, is an adipokine implicated in obesity and plays an important role in regulating the defense and immune functions and is also suggested as a pro-inflammatory and immunomodulating marker for periodontitis. Hence, the aim of the present study was to assess the salivary levels of visfatin in obese patients with and without chronic periodontitis and nonobese healthy patients. Materials and Methods: A total of 45 patients were divided into: nonobese healthy (Group 1, n = 15, body mass index [BMI] ≤22.9 and waist circumference [WC] <90 for male patients and <80 for female patients, pocket probing depth [PPD] ≤3 mm, gingival index [GI] <1, and clinical attachment level [CAL] = 0), obese without chronic periodontitis (Group 2, n = 15, BMI ≥25.0 and WC ≥90 for male patients and ≥80 for female patients, PPD ≤3 mm, GI <1, and CAL = 0), and obese with chronic periodontitis (Group 3, n = 15, BMI ≥25.0 and WC ≥90 for male participants and ≥80 for female participants, PPD ≥5 mm, GI ≥1, and CAL ≥3 mm). Whole saliva samples were collected, and visfatin levels were evaluated using standard enzyme-linked immunosorbent assay. The results were analyzed using SPSS and Mann–Whitney analysis. Results: The highest visfatin levels from saliva were detected in Group 3, while the lowest levels were detected in Group 1. Significant differences were found in salivary visfatin concentrations among the three groups. Conclusion: The salivary level of visfatin was higher in obese patients with and without chronic periodontitis. Visfatin may be used as an inflammatory marker for the detection of obesity and periodontal disease.


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